Warplanes and helicopters late Friday carried out airstrikes on Mahambel village in Idlib province, killing 13 civilians including the seven children, the Syrian Observatory for Human Rights said.
A woman was also killed early Saturday in regime rocket fire on the outskirts of the town of Khan Sheikhun in the south of the province, the Britain-based war monitor said.
Idlib, a region of about 3 million people, many of whom fled former rebel-held areas retaken by the government, is the last major bastion of opposition to the Russia-backed Damascus government after eight years of civil war.
The region on Turkey’s doorstep is administered by Syria’s former Al-Qaida affiliate Hayat Tahrir al-Sham, but other jihadist and rebel groups are also present.
Idlib is supposed to be protected from a major regime assault by a September deal between Moscow and Ankara, but Damascus and its Russian ally have ramped up their deadly bombardment of the region since late April.
More than 520 civilians have been killed since then, according to the Observatory.
The United Nations says 25 health facilities in the region have been hit, the latest including the second attack in two months on an underground hospital in the town of Kafranbel on Thursday.
“The attacks happened despite the fact that the coordinates of this hospital had previously been shared with the parties to the conflict in a deliberate, carefully planned effort to prevent any attacks on it,” an UN official said Friday.
“I am horrified by the ongoing attacks on civilian areas and civilian infrastructure as the conflict in northwest Syria continues,” said Mark Cutts, U.N. deputy regional humanitarian coordinator for the Syrian crisis.
Syria’s war has killed more than 370,000 people and displaced millions since it started in 2011 with a brutal crackdown on anti-government protests.